Wound Healing Activity of the Terpinolene Terpene

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A May 2019 study entitled "Wound Healing Activity of Terpinolene and α-phellandrene by Attenuating Inflammation and Oxidative Stress In Vitro" that was published in the peer-reviewed Journal of Tissue Viability explored the "wound healing effects and the anti-inflammatory and antioxidant activities of [the terpenes] terpinolene and α-phellandrene."

The study's authors reported that the monoterpenes (the most simple class of terpenes) terpinolene and α-phellandrene "significantly increased the migration and proliferation of fibroblasts and suppressed the pro-inflammatory cytokines...in a dose-dependent manner." The research noted that, in summary, "terpinolene and α-phellandrene may contribute to broadening clinical options in the treatment of wounds by attenuating inflammation and oxidative stress in vitro."

Terpinolene is one of the eight Super Class terpenes described in this article. No. 21 of the C3 Podcast discussed the research behind the new super class terpene category.

Study Conclusions

"Wound healing is a complex and well-coordinated process involving different cell types and interactions with soluble mediators, growth factors, and cytokines for the repair of injured tissue. Poor wound healing after trauma, surgery, or chronic disease conditions affects millions of people each year and are considered a challenge to healthcare systems globally. Monoterpenes belong to a large and diverse group of organic compounds with diverse biological activities....

Terpinolene molecular structure

"In summary, the results of the present study showed that terpinolene and α-phellandrene, which share similar chemical characteristics, exhibited similar wound healing properties. Using cell-based assays, both compounds effectively stimulated proliferation and migration of fibroblasts, protected macrophages against cellular oxidative damage, and suppressed the production of pro-inflammatory cytokines (IL-6 and TNF-α) and NF-κB activity."

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